Labor and social security attorneys (LSSAs) are involved in various positions in harmonizing work with disease treatment; however, their qualification requirements do not include knowledge about the same. Expectations of their involvement in harmonizing work with disease treatment are insufficient. This study aimed to identify the competencies expected of the labor and social security LSSAs in harmonizing work with disease treatment. In step 1, semi-structured interviews were conducted with LSSAs in this field. In step 2, a draft competency list was created based on the interview results. In step 3, the Delphi method was used to conduct a questionnaire survey among LSSAs who had over 10 consultation cases on harmonizing work with disease treatment, and they were asked about the level of importance (how important they thought it was to promote harmonizing work with disease treatment) and level of achievement (how much they had achieved). We also asked them about the competencies they considered necessary and added them as additional items in the draft. In step 4, the results of the previous step were presented to the participants who had given valid answers in step 3, and they were asked whether they would adopt the items as competencies. Items with an agreement rate of 80% or higher were considered competency items. Additionally, we asked them about the level of importance and level of achievement of the additional items created in step 3. In step 1, 24 LSSAs participated, and in step 2, a draft competency list of six major items, 18 medium items, and 71 minor items was created. In step 3, 49 LSSAs participated and 41 cooperated (response rate: 83.6%). Five items were selected for the draft competency list to be newly added. In step 4, 30 LSSAs cooperated (response rate: 73.1%). None of the items had an agreement rate of less than 80%, and over 40% of the items had an agreement rate of 100%. As a result, six major items, 18 medium items, and 76 minor items were selected for the competency list. This study identified the competencies expected of labor and social security LSSAs in harmonizing work with disease treatment. The results of this study can be used as a reference for developing a systematic training curriculum for LSSAs in this field in the future.

This research aims to investigate steam biomass gasification in a pilot horizontal gasifier using rubber wood pellets (RWPs) and eucalyptus wood chips (EWCs) for producing syngas with an H2/CO ratio range of 1.8 to 2.3 for Fischer-Tropsch synthesis. The study was divided into two parts. One was carried out in a lab-scale reactor to determine the effect of temperature and CaO on the gas product composition and the efficiency of tar removal. Another part was determined by investigating the effect of the steam/biomass (S/B) ratio on the produced H2/CO ratios in the pilot horizontal gasifier, which used the optimum conditions of temperature and % loading of CaO for tar removal according to the optimal conditions from the lab-scale gasifier. The lab-scale gasifier results showed that H2 and CO2 increased with temperature due to primary and secondary water gas reactions and hydrocarbon reforming reactions. The water gas shift and hydrocarbon reforming reaction depressed the CO and CH4 contents with increasing temperature, respectively. The optimum gasifying temperature was 900 °C, which obtained H2/CO ratios of 1.8 for both RWPs and EWCs. The tar yield decreased with increasing temperature and was less than 0.2 wt % when using CaO as a tar-cracking catalyst. The operation of the pilot horizontal gasifier at the operating condition of 900 °C and a S/B ratio of 0.5 using 0.2 wt % loading of CaO for tar removal also produced a H2/CO ratio of 2.0. The supply of an external heat source stabilized the gasifying temperature, resulting in a stable syngas composition and production rate of 2.5 and 2.7 kg/h with H2/CO ratios of 1.8 and 1.9 for the RWPs and EWCs, respectively. In summary, the horizontal gasifier is another effective designed gasifier that showed high-performance operation.

BackgroundWe aimed to determine the similarities and differences in the roles of genic and regulatory copy number variations (CNVs) in bipolar disorder (BD), schizophrenia (SCZ), and autism spectrum disorder (ASD). MethodsBased on high-resolution CNV data from 8708 Japanese samples, we performed to our knowledge the largest cross-disorder analysis of genic and regulatory CNVs in BD, SCZ, and ASD. ResultsIn genic CNVs, we found an increased burden of smaller (<100 kb) exonic deletions in BD, which contrasted with the highest burden of larger (>500 kb) exonic CNVs in SCZ/ASD. Pathogenic CNVs linked to neurodevelopmental disorders were significantly associated with the risk for each disorder, but BD and SCZ/ASD differed in terms of the effect size (smaller in BD) and subtype distribution of CNVs linked to neurodevelopmental disorders. We identified 3 synaptic genes (DLG2, PCDH15, and ASTN2) as risk factors for BD. Whereas gene set analysis showed that BD-associated pathways were restricted to chromatin biology, SCZ and ASD involved more extensive and similar pathways. Nevertheless, a correlation analysis of gene set results indicated weak but significant pathway similarities between BD and SCZ or ASD (r = 0.25–0.31). In SCZ and ASD, but not BD, CNVs were significantly enriched in enhancers and promoters in brain tissue. ConclusionsBD and SCZ/ASD differ in terms of CNV burden, characteristics of CNVs linked to neurodevelopmental disorders, and regulatory CNVs. On the other hand, they have shared molecular mechanisms, including chromatin biology. The BD risk genes identified here could provide insight into the pathogenesis of BD.

日本の地下石油備蓄基地は，岩手県久慈市，愛媛県今治市菊間町及び鹿児島県いちき串木野市の3箇所の地下に建設され，合計約500万m3の原油を常圧で貯蔵している。原油を貯蔵する地下空洞（岩盤タンク）は，堅硬な岩盤内に構築し，自然の地下水と人工の水封水で液密・気密を確保しつつ，タンク内に湧出した水を排水する水封システムを採用している。操業開始から約30年，モニタリングと適切な処置をしながら安全安定操業を行ってきており，本技術報告では，3基地がこれまで経験したいくつかの地震の影響について示すとともに，地震と岩盤タンク湧水量の関係を検討した結果について紹介する。

The present research primarily focuses on the investigation of gate-entry stability of longwall trial panel under weak geological condition in Indonesia coal mine by means of numerical analysis. This work aims at identifying appropriate roof support at 100 m and 150 m of depth during gate development. Due to depth depending competency of dominant rock, the stability of gate-entry at 100 m of depth can be optimized by leaving at least 1 m of remaining coal thickness (RCT) above and below the gate-entry. The appropriate support for the trial panel gate-entry is steel arch SS540 with 1 m and 0.5 m spacing for 100 m and 150 m of depth, respectively. The influence of panel excavation on gate-entry is also discussed. Regarding the aforementioned influence, the utilization of additional gate mobile support is recommended at least 10 m from the longwall face.