Fresh fruits are considered as a healthy source of water soluble vitamins. Vitamins are needed for metabolic reactions, their deficiency or increased intake lead to different irregularities in normal metabolism. Our work aimed to determine some different types of vitamin B as B1, B6, B2, B9 and B17 and applications of different methods of extracting and analyzing them by HPLC then loading them on chitosan nanoparticles (CSNPs) to study its biological applications and cytotoxicity on different cell lines. HPLC analysis of acid hydrolysis samples showed that thiamine (B1) was found in range of 88.13-96.66 %, riboflavin (B2) was 95 - 96.216 %, pyridoxine (B6) was 95.22 - 100 %, folate (B9) 95.6-96.94 % while amygdalin (B17) was 94.975-96.66 %. After loading vitamins with chitosan, the results showed cytotoxic activities of Vitamins B1, B2, B6, B9 and B17 as these extracted vitamins were tested against different cancerous and normal cell lines. Vitamin B6 nanoparticles showed the best cytotoxic effect on different cancerous cell lines as Hepatocelluar carcinoma (HePG2), Mammary gland Breast cancer (MCF-7) and Epitheliod Carcinoma Cervix cancer (Hela) and it can be considered as a safe compound on normal cell as normal human lung fibroblast cell line (WI-38).

Fresh fruits are considered as a healthy source of water soluble vitamins. Vitamins are needed for metabolic reactions, their deficiency or increased intake lead to different irregularities in normal metabolism. Our work aimed to determine some different types of vitamin B as B1, B6, B2, B9 and B17 and applications of different methods of extracting and analyzing them by HPLC then loading them on chitosan nanoparticles (CSNPs) to study its biological applications and cytotoxicity on different cell lines. HPLC analysis of acid hydrolysis samples showed that thiamine (B1) was found in range of 88.13-96.66 %, riboflavin (B2) was 95 - 96.216 %, pyridoxine (B6) was 95.22 - 100 %, folate (B9) 95.6-96.94 % while amygdalin (B17) was 94.975-96.66 %. After loading vitamins with chitosan, the results showed cytotoxic activities of Vitamins B1, B2, B6, B9 and B17 as these extracted vitamins were tested against different cancerous and normal cell lines. Vitamin B6 nanoparticles showed the best cytotoxic effect on different cancerous cell lines as Hepatocelluar carcinoma (HePG2), Mammary gland Breast cancer (MCF-7) and Epitheliod Carcinoma Cervix cancer (Hela) and it can be considered as a safe compound on normal cell as normal human lung fibroblast cell line (WI-38).

Lactic acid bacteria (Lac B) are a prominent class of microorganisms that are capable of producing a variety of antimicrobial peptides or bacteriocins, which have inhibitory action on closely or far related organisms. In this study, we isolate and characterize bacteriocin from Lactococcus garvieae which, after dialysis showed significant activity against some bacterial and fungal strains, as well as anticancer activity against HT29 (Colorectal adenocarcinoma) cell lines.

The investigation of potential adverse health effects of occupational exposures to ionizing radiation, on nuclear plant workers, is an important area of research. In this study, we aimed to calculate the incidence and risk of cancer development and mortality during last five years (2015-2019). 456 nuclear industry workers were included into this study (39 cancer patients and 417 healthy). For this cohort, the cancer mortality has been assessed by data obtained from national health registry excluded for the probability of known causes of death. The associations between cumulative occupational radiation exposures (radon, gamma radiation and long-lived radionuclides) and cancer mortality were calculated. Radon and Gamma exposure was significantly higher among workers who developed cancer [8.4 (0; 3,224.5) vs. 19.7 (0; 128.4), p=0.03] and [12.0 (2.1; 110.0) vs. 24.5 (0; 470.1), p=0.02]. However, no significant association was found between long-lived radionuclides and risk of cancer (p=0.07).

Objective: Small cell lung cancer (SCLC) may be considered as a major health concern as a leading cause of cancer related mortality worldwide. Despite intensive management, SCLC may follow an aggressive disease course with recurrent and/ or metastatic disease in a considerable proportion of the patients. Herein, we assess multimodality imaging based treatment volume definition for reirradiation of recurrent SCLC. Literature Review: Definition of treatment volume by multimodality imaging with incorporation of positron emission tomography (PET) or by computed tomography (CT)-simulation images only has been evaluated with comparative analysis for patients reirradiated for recurrent SCLC. Results: A multidisciplinary team of experts from surgery, medical oncology, radiation oncology, and pulmonology has been involved in individualized patient evaluation. Decision making for reirradiation of patients with recurrent SCLC has been performed after comprehensive assessment considering the lesion size, localization and association with critical structures, previously administered treatments at initial diagnosis, and time interval from initial RT. Treatment volume determination by CT-only imaging and by CT-PET fusion based imaging has been assessed with comparative analysis. Ground truth target volume has been found to be identical with treatment volume determination by CT-PET fusion based imaging as the primary result of this study. Conclusion: Incorporation of PET in RT planning process may be considered for patients receiving reirradiation for recurrent SCLC. Clearly, further investigation is required to shed light on this issue.

Background: To assess the knowledge, attitude, and practice regarding prevention and screening of breast cancer among reproductive-age women. Methods: A descriptive cross-sectional study was carried out in 110 women aged 15 – 45 years old. 5- point Likert scale and interview schedule was performed with the help of structured and semi-structured questionnaire to collect data. Finally, collected data are analyzed by using the descriptive statistical method. Findings: Majority of the respondents i.e. 71.8% had heard about breast cancer. 42.7% responded that fitness could be the best preventive measure with a mean value of 2.21. A large number of participant's i.e. 76.36% strongly agreed about development from breast cells and 49.1% reacts surgery is only the treatment option for breast cancer. 46.4% of them agreed that breast self-examination (BSE) is a necessary tool for early detection of breast cancer. Conclusion: The knowledge regarding breast cancer screening and prevention is lacking in many participants and it should be spread worldwide which helps to decrease the incidence and could save the lives of many women. Keywords: Attitude; Breast cancer; Knowledge; Practice; Prevention & Screening, reproductive age women