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The Journal of Knee Surgery Reports

The Journal of Knee Surgery has ever acknowledged the importance of publishing high-quality case reports. Almost 2 years ago, one special supplement of this journal aimed this specialmodality of publication. As the number of submissions continued to increase, in 2014, a sister periodical was launched to address this purpose, the Journal of Knee Surgery Reports. The main scope of the new journal is to offer a premium outlet for authors willing to share interesting and welldocumented clinical cases related to knee pathology. We believe that this is a true opportunity to present rare clinical conditions, original decision-making approaches, creative solutions, and ultimate outcomes that make every case unique. In this first printed edition, we collected 14 articles, which were published online first. A variety of topics have been covered, from rare knee tumor presentations to compartment syndrome following total knee replacement. Wewould like to thank all authors, reviewers, and editorial board members for their relevant contributions to the first printed issue of this journal. To our readers, we would like to wish a rewarding experience. The Journal of Knee Surgery Reports aims to be a reference for excellence in knee-related clinical cases. To accomplish this goal, we do invite you to join us and share your expertise with a large community of knee surgeons. Be our guest and collaborator. You are very welcome to the Journal of Knee Surgery Reports. Editorial

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Drug Reaction with Eosinophilia and Systemic Symptoms Associated with a Vancomycin-Impregnated Spacer

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe adverse drug reaction with a mortality rate near 10% characterized by erythematous cutaneous eruption, multiorgan involvement, and hypereosinophilia. This case report highlights a patient who developed DRESS in the setting of intravenous vancomycin and a vancomycin and tobramycin-impregnated (PROSTALAC, DePuy Synthes, Warsaw, IN) functional spacer. The spacer was placed during the revision of a left total knee replacement complicated by a septic joint. To our knowledge, this is the third reported case of DRESS associated with vancomycin-impregnated spacers. As DRESS is a potentially life-threatening reaction and the principal treatment is withdrawal of the precipitating drug, it is important to consider this clinical entity and discontinue all forms of the causative agent. Patients with DRESS may develop a diffuse cutaneous eruption, respiratory failure, acute kidney injury, elevated liver enzymes, lymphadenopathy, and/or hemodynamic instability following intravenous infusion of antibiotics or placement of antibiotic-impregnated spacers, beads, or bone cement. Interestingly, this patient had a prominent and progressive erythematous eruption surrounding the left knee that improved after operative removal of the spacer. At 6 week hospital follow-up, the patient's systemic signs and symptoms had essentially resolved.

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