ABSTRACT Purpose The study seeks to address the influence of different facets of business-to-business (B2B) relationship marketing on internationalization effectiveness, by taking into account the turbulent environment generated by the COVID-19 pandemic. The focus falls on the factors that generate, frame, catalyze, sustain and strengthen international business relationships between managers from organizations with converging interests. Methodology B2B relationship marketing in the international arena is analyzed by means of various angles such as business convergence, business context, interpersonal compatibility, business credibility and network interconnections as availed by the “new normal” triggered by the COVID-19 pandemic. A questionnaire-based survey with 158 business owners and managers from European industrial companies was carried out during November 2023 to investigate the configuration and dynamics of B2B relationship marketing in the unprecedented and systemic COVID-19 crisis. Data was analyzed via structural equation modeling using SmartPLS 4. Findings The findings showed that while business convergence remains a strong influencer of all the other relational dimensions, the restrictions and limitations engendered by the pandemic have also altered international B2B relationship marketing to such an extent that the only significant factor for internationalization effectiveness relies on business networking. Research and practical implications The study has both theoretical and practical implications, bringing forward a topical perspective on international B2B relationships during COVID-19 disruptions and their impact on the effectiveness of international operations. Originality The study advances a phenomenological view of the unprecedented changes and their influences on the overseas operations of SMEs in a particular field. It complements and adds to the literature by stressing a more articulated relationship-centric architecture, which probed relevance during the pandemic.

ABSTRACT This paper examines the adoption of brutalism in the work of Israeli landscape architects. Since the 1960s, Brutalism made its way from Europe to Israel by leading architects at the time. In parallel, landscape architects also considered Brutalism appropriate to the young state, and the use of concrete as a cheap and readily available construction material. They demonstrated creativity by constructing plazas, outdoor housing complexes, playgrounds and parks, essentially laying a cement carpet across the landscape. The absence of a well-established local outdoor material tradition, coupled with climatic and maintenance considerations, encouraged the burgeoning prominence of outdoor Brutalism in Israel.

ABSTRACT The 2015 Paris climate Agreement established a ‘bottom-up’, pledge and review process as international climate governance’s central framework. The European Union’s governance framework – the Energy and Climate Governance Regulation (EUGR) – uses a similar architecture. Both require states to regularly create, revise and update national plans while ramping up ambitions towards meeting the collectively agreed commitments and sharing features of Experimentalist Governance. This paper contributes to the debate on experimentalist climate governance’s effectiveness. It assesses systematically the implementation of EUGR based on documentary analysis and expert interviews. We find that the process has been partially effective in raising ambitions but has remained incremental, technocratic and depoliticised. Experimentalist processes such as the EUGR and Paris Agreement require a high level of public and stakeholder engagement to operate but politicisation can have, in turn, adverse effects. This raises questions regarding the ability of experimentalist climate governance to deliver, alone, rapid emission reductions.

Bladder cancer is characterized by frequent mutations, which provide potential therapeutic targets for most patients. The effectiveness of emerging personalized therapies depends on an accurate molecular diagnosis, for which the accurate estimation of the neoplastic cell percentage (NCP) is a crucial initial step. However, the established method for determining the NCP, manual counting by a pathologist, is time-consuming and not easily executable. To address this, artificial intelligence (AI) models were developed to estimate the NCP using nine convolutional neural networks and the scanned images of 39 cases of urinary tract cancer. The performance of the AI models was compared to that of six pathologists for 119 cases in the validation cohort. The ground truth value was obtained through multiplexed immunofluorescence. The AI model was then applied to 41 cases in the application cohort that underwent next-generation sequencing testing, and its impact on the copy number variation (CNV) was analyzed. Each AI model demonstrated high reliability, with intraclass correlation coefficients (ICCs) ranging from 0.82 to 0.88. These values were comparable or better to those of pathologists, whose ICCs ranged from 0.78 to 0.91 in urothelial carcinoma cases, both with and without divergent differentiation/ subtypes. After applying AI-driven NCP, 190 CNV (24.2%) were reclassified with 66 (8.4%) and 78 (9.9%) moved to amplification and loss, respectively, from neutral/minor CNV. The neutral/minor CNV proportion decreased by 6%. These results suggest that AI models could assist human pathologists in repetitive and cumbersome NCP calculations.

ABSTRACT In this study, we investigated how early career teachers implemented individual goals set in a self-management training course in the context of professional development, followed by online coaching (OC) designed to support transfer to practice and self-regulation. We conducted qualitative analyses of coaches’ OC reports from 60 teachers and a case study including three teachers’ and their coaches’ perspective on the process of goal implementation. Two action-oriented patterns of goal pursuit (pragmatic and reflective) and one low focus and engagement pattern were identified. The OC helped teachers to deal with school-, stress-, and career-related challenges, and to reflect. We conclude that OC is suitable to support teachers’ self-regulation and to empower them, provided they engage with it. We argue that adaptive coaching models, based on principles of professional coaching, including goal orientation, should be further developed for teacher education.

ABSTRACT This paper demonstrates how Latinx/a/o parents drew on various forms of capital to support their children’s college application, choice, and transition during the pandemic. Latinx/a/o parents encouraged and supported their children by maintaining high college aspirations despite COVID-19 concerns, entrusting their children with their college choice decisions despite sometimes conflicting with their own, and supporting their children in their college transition through consejos and encouragement. This study contributes to the literature by centering Latinx/a/o parents’ counternarratives that highlight their ongoing commitment to supporting students’ college aspirations despite deficit notions exacerbated by the pandemic.

ABSTRACT This study aimed to explore the experiences of a nature-based outdoor activity program for children and adolescents who have survived a serious illness like cancer, as well as their siblings. The study utilised individual semi-structured interviews (N=10) and focus group interviews (N=8) to investigate the experiences of participants, parents, and program leaders. Data was analysed using interpretative phenomenological analysis (IPA), resulting in two main themes: 1) What nature affords, and 2) Influence on the child. The various affordances in nature influenced the child in multifaceted ways: mastery experiences, autonomy, motivation, awareness, stress reduction and affect regulation, belongingness and social support. These categories are connected to the main agentic features: intentionality, forethought, self-reactiveness and self-reflectiveness. The Nature school contributes to the development of agency within children. They become more capable of self-care, and there are examples of the children transferring this knowledge to other aspects of their daily lives.

Reactivating place cells during sharp-wave ripples in the hippocampus is important for memory consolidation. However, whether hippocampal reactivation is affected by the values of events experienced by the animal is largely unknown. Here, we investigated whether place cells in the dorsal (dHP) and intermediate hippocampus (iHP) of rats are differentially reactivated depending on the value associated with a place during the learning of places associated with higher-value rewards in a T-maze. Place cells in the iHP representing the high-value location were reactivated significantly more frequently than those representing the low-value location, characteristics not observed in the dHP. In contrast, the activities of place cells in the dHP coding the routes leading to high-value locations were replayed more than those in the iHP. Our findings suggest that value-based differential reactivation patterns along the septotemporal axis of the hippocampus may play essential roles in optimizing goal-directed spatial learning for maximal reward.

There is a strong relationship between metazoan body size and extinction risk. However, the size selectivity and underlying mechanisms in foraminifera, a common marine protozoa, remain controversial. Here, we found that foraminifera exhibit size-dependent extinction selectivity, favoring larger groups (>7.4 log10 cubic micrometer) over smaller ones. Foraminifera showed significant size selectivity in the Guadalupian-Lopingian, Permian-Triassic, and Cretaceous-Paleogene extinctions where the proportion of large genera exceeded 50%. Conversely, in extinctions where the proportion of large genera was <45%, foraminifera displayed no selectivity. As most of these extinctions coincided with oceanic anoxic events, we conducted simulations to assess the effects of ocean deoxygenation on foraminifera. Our results indicate that under suboxic conditions, oxygen fails to diffuse into the cell center of large foraminifera. Consequently, we propose a hypothesis to explain size distribution-related selectivity and Lilliput effect in animals relying on diffusion for oxygen during past and future ocean deoxygenation, i.e., oxygen diffusion distance in body.