Pseudocyclic arylbenziodoxaboroles are unique aryne precursors under neutral aqueous conditions that selectively react with organic sulfides, forming the corresponding sulfonium salts. This reaction is compatible with various substituents (alkyl, halogen, CN, NO2, CHO, and cyclopropyl) in the aromatic ring or alkyl group of the sulfide. Similar reactions of sulfoxides afford o-hydroxy-substituted sulfonium salts. The structures of key products were confirmed by X-ray analysis.

Various five-membered cyclic dibenzobromolium salts (dibenzo[b,d]bromol-5-ium chloride, nitrate, hydrogen sulfate, dihydrogen phosphate, trifluoroacetate, and tetrafluoroborate) were prepared by diazotization-cyclization of 2'-bromo-[1,1'-biphenyl]-2-amine in solution of appropriate acids. The chlorolium analogues (iodide, trifluoroacetate, and tetrafluoroborate) were obtained by a similar procedure. Additional dibenzohalolium derivatives (dibenzo[b,d]bromol-5-ium and dibenzo[b,d]chlorol-5-ium azides, bis(trifluoromethanesulfonyl)imidates, thiocyanates, and trifluoromethanesulfonates) were prepared by anion exchange. Structures of ten of these dibenzohalolium derivatives were established by X-ray analysis. Bond distances and angles for the halogen atoms in different dibenzohalolium derivatives were summarized and discussed.

We report a greener peptide coupling using bicyclic benziodazolone and triarylphosphine as coupling reagents. Bicyclic benziodazolone also works as a base and can be recovered as the corresponding iodine(I) compound after use, which can be converted to the original iodine(III) reagent by electrolytic oxidation.

Abstract End-of-life care patients use home-visit nursing services under Japanese long-term care insurance; however, they require a care manager to implement the care plan. However, the cooperation procedure of home-based medical care between visiting nurses and care managers has not been adequately researched. Thus, this study aimed to clarify the presence of support between visiting nurses and care managers to be adapted to this situation. This study was conducted in March and April 2023 at home-visit nursing stations located in a prefecture in Japan. Self-administered questionnaires were mailed to 192 visiting nurses in Japan, and 136 response forms (70.8%) were received through postal mails. A total of 130 questionnaires (67.7%) were determined to be valid responses, which also included the participants’ written consent for research. The presence or absence of work experience and the importance of collaboration in the preparatory, introductory, stable, and near-death stages of end-of-life care were answered. The presence of work experience at each stage was over 53.1%. The importance of collaboration at each stage was over 76.9%. Query regarding collaborating well with care managers was answered on a scale from 0 to 100 %. Good collaboration with care managers had an average score of 75.4%. The presence or absence of experience and the importance of collaboration items were clarified at each stage. The research findings could contribute to the development of education and training. This work was supported by JSPS KAKENHI Grant Number JP21K02802.

AbstractBackgroundThe average length of stay in general beds is about 16 days in Japan . Providing quality care to inpatients with dementia has been a challenge in acute hospitals. In Japan, “in‐hospital daycare”, in which patients gather in specific places in the hospital for recreation and rehabilitation, is increasing. Therefore, we aimed to clarify the current situation of “in‐hospital daycare” at hospitals in Japan and the ripple effect on dementia care in wards.MethodA web‐based survey was conducted on 1,101 nurses working in hospitals who are certified as experts of dementia or geriatric care.ResultData were obtained from 272 nurses (response rate: 24.7%). 38 nurses (14%) have provided “in‐hospital daycare”, and 51 nurses (18.8%) provided it before the COVID‐19 pandemic. We analyzed data of these 89 nurses.91.0% of them recognized that “in‐hospital daycare” was effective for the patients who participated. In addition, they reported the ripple effect on ward nurses. Ripple effects are 〈ward nurses are more supportive of patient activity/diversional activity 〉〈Ward nurses are more aware of patient strengths〉〈Ward nurses noticed new aspects of patients and backgrounds, and deepened their understanding of patients〉〈Increased conversations between ward nurses and patients〉and so on.ConclusionAlthough only about 30% of facilities provide “in‐hospital day care”, it has not only an effect on participating patients, but also has a ripple effect on ward nurses. Results suggest that it contributes to improving the quality of dementia care in the ward.