While emerging theories suggest that vascular dysfunction may occur concurrently with the amyloid cascade in Alzheimer disease (AD) pathogenesis, the role of vascular components as primary neurodegeneration triggers remains uncertain. The aim of this retrospective, population-based cohort study conducted in Korea was to explore the link between nonarteritic anterior ischemic optic neuropathy (NAION) and dementia risk. In this nationwide, population-based, retrospective cohort study, we identified newly diagnosed NAION from 2010 to 2017 in the Korean National Health Insurance Service database. The primary outcome was new dementia diagnoses confirmed by new ICD-10 claims coupled with antidementia medication prescriptions. We assessed dementia risk using hazard ratios (HRs) with 95% CIs over an average 2.69-year follow-up after a 1-year lag period. The cohort consisted of 42,943 patients with NAION and 214,715 age-matched and sex-matched controls without NAION (mean age 61.37 years ± 10.75 SD, 55.48% female). The study found a higher risk of all-cause dementia (ACD; HR 1.28, 95% CI 1.20-1.36), AD (HR 1.27, 95% CI 1.18-1.36), vascular dementia (VaD; HR 1.31, 95% CI 1.09-1.58), and other dementia (HR 1.39, 95% CI 1.11-1.73) among patients with NAION, regardless of other potential confounding factors such as age, sex, lifestyle behaviors, economic status, and preexisting health conditions. In subgroup analysis, the associations between NAION and ACD were stronger in the younger age group (HR 1.83 for those younger than 65 years vs 1.23 for those 65 years or older; p for interaction <0.001). Moreover, the association of NAION with both ACD and VaD was particularly strong among current smokers. We found a significant association between NAION and increased risk for ACD, AD, VaD, and other dementia even after adjusting for potential confounders such as lifestyle, health conditions, and demographic factors within a nationwide cohort. This study highlights the potential role of vascular pathology in dementia progression and suggests that NAION may serve as a robust predictor for dementia, highlighting the need for comprehensive neurologic assessment in patients with NAION. Further research is needed to clarify the association between NAION and dementia risk.

Symptomatic macromastia (enlarged breasts) is a syndrome of persistent headache, neck and shoulder pain, thoracic kyphosis, painful shoulder grooving from bra straps, inframammary rash, backache, and upper extremity paresthesias. Up to 89% of the 100,000 US women undergoing breast reduction surgery (reduction mammoplasty) annually report headache preoperatively with many endorsing postoperative headache improvement. Headache is one insurance indication to cover surgical reduction, and peak prevalence of migraine matches the average age of women with macromastia at time of surgery. Little is known about the influence of macromastia on headache. The goal of our narrative review is to understand the evidence for and potential mechanisms underlying macromastia-related headache. A literature search was performed in PubMed Medline using concepts "breast hypertrophy," "macromastia," "headache," "migraine," "breast reduction," and "reduction mammoplasty" excluding limits on age, language, publication date, or study type. Supplemental literature searches were performed to provide a comprehensive understanding of potential mechanisms underlying macromastia-related headache. We identified 25 studies describing macromastia-associated headache in the setting of reduction mammoplasty, with 23 original research studies (retrospective, n = 12, prospective, n = 11) totaling 3,799 patients, 1 systematic review, and 1 meta-analysis. Most (24/25) were published in Plastic Surgery, one in Internal Medicine, and none in Neurology. Wide ranges were identified for preoperative headache prevalence (2%-89%) and postoperative headache improvement (34%-100%). Studies described headache as "myofascial" or "tension-type" without detailing headache definitions, chronicity, headache screening method, or neurologic examination. Potential pathophysiologic mechanisms of macromastia-associated headache include structural, mechanical, psychosocial, and hormonal. No studies on macromastia-associated headache and reduction mammoplasty are published in Neurology. This important women's health topic remains unexplored in fields outside Plastic Surgery. Many questions remain unanswered that are important for neurologists to understand, including which headache type(s) women with macromastia experience and which headache type(s) respond to surgical intervention.

In recent years, advances in interventional bronchoscopy have led to safer and more effective solutions for the diagnosis and treatment of respiratory diseases. However, the techniques currently used to diagnose and treat peripheral pulmonary lesions (PPL) have certain limitations. Robotic-assisted bronchoscopy (RAB) offers a new solution to these limitations. Currently, three RABs have been approved by the US Food and Drug Administration (FDA) and are successfully marketed, while two domestic RABs are in the research and development stage. This article provided an overview of the advantages and disadvantages of various techniques and introduced five RABs in detail. It also discussed the advantages and disadvantages of RAB technology and future trends in its development.

To explore the research hotspot, development trend and existing problem of artificial intelligence (AI) application in the field of acupuncture and moxibustion by using bibliometric method. Relevant articles of AI application in the field of acupuncture and moxibustion published in CNKI, Wanfang, VIP, PubMed and Web of Science from the database establishment to September 17, 2023 were searched. Excel 2019, CiteSpace 6.2.R4 and VOSviewer 1.6.19 were used to draw visual map of the number of publication, authors, research institutions and keywords, and further analyzed the research hotspot and trend. A total of 443 Chinese articles and 68 English articles were included. The number of annual publication of Chinese articles showed an overall increasing trend, while the number of publication of English articles was less, with a growing trend from 2020. Keywords analysis showed that "Machine learning", "neural network", "deep learning", "data mining", "robot" and other AI technologies were developing around acupuncture and moxibustion diagnosis and treatment of disease, efficacy prediction, teaching and intelligent equipment development. However, the research on the application of AI in the field of acupuncture and moxibustion is in the preliminary stage of development, and in the future, it is necessary to strengthen the communication and cooperation among the teams, to further explore the AI system in line with the characteristics of acupuncture and moxibustion diagnosis and treatment, and to promote the development of the digitalisation, intellectualisation and industrialisation of acupuncture and moxibustion.

The Jingjin therapy and rehabilitation medicine share commonalities and complement each other. The application of Jingjin therapy from a rehabilitation perspective can broaden the development path of traditional Chinese medicine (TCM) rehabilitation. This paper, based on relevant literature and research findings, elaborates on the connection between Jingjin syndrome differentiation acupuncture and rehabilitation assessment and treatment. It discusses the application framework of Jingjin's preventive treatment theory in disease prevention and rehabilitation, and forecasts the research model of Jingjin rehabilitation medicine from an integrative perspective of Chinese and western medicine. This study aims to improve the rehabilitation application thinking of Jingjin therapy and enrich the application methods and treatment approaches of TCM rehabilitation medicine.

Tuberculosis, a chronic infectious disease caused by Mycobacterium tuberculosis, has long posed significant challenges to both medical professionals and patients in its diagnosis and treatment. The need for regular follow-up visits has resulted in a significant economic and logistical burden for patients and a strain on healthcare resources. However, the recent rapid development of Internet technology has significantly enhanced the role of telemedicine in the health care of tuberculosis. This proposal aims to provide a comprehensive overview of the various aspects of telemedicine in the management of tuberculosis. It covers functional positioning, medical qualifications, scope of application, management team, operational model, medical standards, medication evaluation, precautions, risk management. It is intended to serve as a reference for healthcare professionals in the practical application of telemedicine in tuberculosis care.【Expert Recommendation 1】: To provide the further online services for tuberculosis patients who have already had a face-to-face consultation and been diagnosed with tuberculosis. Telemedicine in tuberculosis care includes confirmation of diagnosis, treatment, health counseling, management, educational initiatives, and the initial assessment and management of new symptoms and signs.【Expert Recommendation 2】: The qualifications for telemedicine in tuberculosis care require that the attending physician has a valid medical license and has at least three years of clinical experience in tuberculosis.【Expert Recommendation 3】: The primary target group for online tuberculosis care are patients who are undergoing routine follow-up visits. Certain examinations and test results are mutually recognized within certain regions.【Expert Recommendation 4】: The management team for telemedicine in tuberculosis care is consist of specialist physicians from tuberculosis medical institutions or third-party internet medical organizations, together with information technology staff.【Expert Recommendation 5】: The informatization framework for telemedicine in tuberculosis care includes referrals between higher and lower-level institutions, as well as online and offline referrals. Methods for online follow-up consultations include text-based and video consultations.【Expert Recommendation 6】: Standards for telemedicine in tuberculosis care must be in line with government documents. Regular monitoring and evaluation of the safety and efficacy of anti-tuberculosis therapy is needed, with guidance for patients to seek further treatment at an offline medical institution if necessary.【Expert Recommendation 7】: The attending physician must comply with regulations when documenting patient care and issuing prescriptions, which are valid only after review and approval by a pharmacist.【Expert Recommendation 8】: Healthcare providers are encouraged to use digital platforms, including social media, short video platforms, and mini-programs, to disseminate health information to patients and their families.【Expert Recommendation 9】: If the attending physician discovers adverse events in internet medical treatment, it is necessary to report them immediately to the adverse reaction reporting system of the hospital relying on internet medical treatment.【Expert Recommendation 10】: The attending physician should handle any disputes or complaints about online diagnosis and treatment in accordance with applicable laws, regulations, and guidelines.【Expert Recommendation 11】: Strict confidentiality of patient information must be maintained in online tuberculosis care, and patient consent before data can be used for educational or research purposes.【Expert Recommendation 12】: For primary care facilities that do not have the necessary resources for online diagnosis and treatment, we recommend establishing satellite centers, implementing simplified remote care systems, and utilizing mobile devices in collaboration with nearby hospitals that can provide remote care. This approach aims to increase the capacity of primary care facilities to provide telemedicine service.

With the increasing incidence of myopia year by year and the continuous progress of various treatment techniques, laser corneal refractive surgery has become one of the important ways to correct refractive errors. The rational drug use in the perioperative period is important for the success of surgery and reduction of complications. In 2019, based on the development of laser corneal refractive surgery in China, experts from the Refractive Surgery Experts Group of Ocular Microcirculation Branch of Chinese Society of Microcirculation and the Ophthalmology Branch in the Chinese Medical Association formed the "Chinese Expert Consensus on the Perioperative Medication in Laser Corneal Refractive Surgery (2019)". To further promote the expansion of new clinical technologies and surgical methods, and to improve surgical efficacy, the Refractive Surgery Experts Group of Ocular Microcirculation Branch of Chinese Society of Microcirculation, according to the latest domestic and foreign research results, has recently updated the consensus after a collective discussion.

22q11.2 deletion syndrome (22q11.2DS) is the most common chromosomal microdeletion disorder. Its phenotype is highly variable with incomplete penetrance. 22q11.2DS is a rare disease, and the research progress is relatively slow, which has restricted its treatment and intervention. In recent years, much progress has been made in the pathogenic mechanism and genome-wide association study of 22q11.2DS. In this review, the pathogenesis of 22q11.2DS was summarized. Thereafter, the molecular and pathological mechanisms of TBX1 and DGCR8 genes were clarified. Finally, factors affecting the penetrance of cardiac and immune system phenotypes were reviewed. This review may enhance the understanding of 22q11.2DS and has important clinical implications on the prenatal diagnosis, genetic counseling, treatment and intervention of this disease.

Congenital joint synostosis (CJS) is a functional impairment resulting from failure in joint morphogenesis during embryonic development. Clinically, it may be classified as syndromic (sCJS) and non-syndromic (nsCJS) disorders. Common sCJS include chromosomal disorders such as Klinefelter syndrome and single-gene disorders like Apert/Pfeiffer/Crouzon syndromes, Holt-Oram syndrome, Ehlers-Danlos syndrome, and Radial-ulnar synostosis with thrombocytopenia, presenting with multiple system/organ anomalies. By contrast, nsCJS manifest with only joint abnormalities, affecting one or multiple joints. This review has focused on human nsCJS and its genetic etiology. To date, variants in seven genes (NOG, GDF5, FGF9, GDF6, FGF16, SMAD6, and MECOM) have been identified as causative factors for nsCJS. This review has focused on such genes and provided a comprehensive review for the clinical phenotypes, genetic patterns, common variants, and underlying mechanisms associated with nsCJS based on a literature review. In addition, it has also analyzed other candidate genes for nsCJS within the context of relevant signaling pathways involved in joint morphogenesis.

DNA methylation is an important epigenetic regulatory mechanism which plays a crucial role in cell differentiation and development. Its function is closely related to DNA methyltransferase 3 alpha (DNMT3A), which can affect gene expression and stem cell differentiation. The mutation rate of the DNMT3A gene is relatively high in Acute myeloid leukemia (AML), but its type and pathogenic mechanism are not yet clear. Further research on DNMT3A may help to identify its pathogenic targets and provide a basis for precise treatment of AML. This article has provided a review for the research progress on the expression of the DNMT3A gene in AML.