Abstract
Continuity bone repair necessitates the use of autogenous bone placed into the continuity defect to promote bone healing. The use of bone graft substitutes such as allografts and xenografts may provide the necessary osteoconductive scaffold for bone formation across a critical sized defect. The use of platelet rich plasma (PRP) has been implicated to enhance bone formation when used with autogenous bone, and also when used in conjunction with xenografts in craniotomy defects. In this study we investigated the use of PRP or platelet poor plasma (PPP) in combination with a xenograft of human mineralized bone (Puros; Centerpulse Dental, Carlsbad, CA) to heal zygomatic arch defects in the dog. Previous evaluation of the displaced zygomatic arch model has shown that a 10-mm lateral movement of the arch provides a defect that would not heal without appropriate grafting. The aim of this study was determine if there was a difference between PRP and PPP to enhance bone formation when used with xenograft.
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