Abstract
Thirteen malignant and 4 benign human mammary tumours have been studied in vitro by a method based on the contiguous culture of the tumour explants and of fragments of male and female gonads, in order to detect a possible hormone-dependence. Twenty hours after explantation, labelled thymidine or amino acids were added to the medium. Cultures in the presence of testicular fragments resulted mostly in a significant decrease of the incorporation of labelled substance by the tumour explants. In two cases, a significant stimulation occurred. In the presence of ovarian fragments, the results were less significant. Several benign tumours were also hormone-dependant. The results do not suggest any relation with sex chromatin diagnosis of mammary carcinoma, neither with the patient's age, nor with histological findings.
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