Abstract
Investigations on the role of the reticuline converting enzyme for the biosynthesis of tetrahydro-protoberberine (THPB) alkaloids gave the following results: 1. The enzyme activity in cell suspension cultures of Macleaya microcarpa increases before onset of the biosynthesis of THPB alkaloids. 2. The reticuline converting enzyme and THPB metabolism show a concomitant presence in different plant species. 3. The enzyme converts not only (±)-reticuline but also (±)-laudanidine into THPB alkaloids. Obviously, it is specialized in the conversion of certain benzyltetrahydroisoquinoline alkaloids. An essential prerequisite for the enzymatic reaction seems to be the hydroxyl group at the C-atom 3′ of the given skeleton. — According to these findings we propose to replace the name “reticuline converting enzyme” by “berberine bridge enzyme”.
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