Abstract
An attempt has been made to demonstrate the feasibility of quantitating by light microscopy and histoplanimetry the pathology of placental maturation associated with maternal diabetes mellitus. The size of chorionic villi, the development of chorionic vessels, stroma edema, and the distribution of these findings were used as criteria to assess the degree of the abnormality. In addition, the size of individual villi and the distribution of these villi over areas of known size were estimated. The results of these methods coincided in 72% of 25 cases thus studied. The advantages and disadvantages of both methods were evaluated. For the correlation of placental alterations on the one hand and of maternal and fetal pathology on the other, a quantitative assessment of placental maturation appears urgently required.
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