Abstract
Dendrimer nanoparticles (DNPs), which have been studied extensively as drug delivery systems, can be synthesized easily with zirconium without chelators. A UV/Vis spectrophotometer and a Dynamic Light Scattering (DLS) analysis were used to confirm the synthesis and the particle size of the composite. Compound B synthesized using a chelator compound was found to be more complex than compound A, and natZr was found to bind at a low yield through Scanning Electron Microscopy-Energy Dispersive X-ray Spectrometer (SEM-EDS) and Inductively Coupled Plasma-Mass Spectrometer (ICP-MS). In PBS (1×), The binding was confirmed to be strong and stable at 99% stability or more. The stability to human serum was very good with a value of about 98%. The stability of the bound 89 Zr was confirmed to be stable for 160 minutes through the evaluation of serum stability. Using CT-26 and MDA-MB-231, We also were able to confirm the difference in the cell uptake of 89Zr-DNPs. After 24 hours, a high cell uptake of close to 40% was observed. Positron Emission Tomography (PET) images were observed, it was confirmed that no accumulation of 89 Zr-DNPs in the bones and its stability in the body.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
