Abstract
La(III), Zr(IV), and Ce(IV) chelates of 2-[(4-[(Z)-1-(2-hydroxyphenyl)ethylidene]aminobutyl)-ethanimidoyl]phenol were synthesized and characterized by using several physical techniques. The Schiff base was obtained by refluxing of o-hydroxyacetophenone with 1,4-butanediamine in 2 : 1 molar ratio. The CHN elemental analysis results showed the formation of the Schiff base and the chelates has been found to be in 1 : 1 [M : L] ratio. The molar conductance measurements revealed that all the chelates are nonelectrolytes. Structural elucidations of the ligand and its chelates were based on compatible analytical and spectroscopic evidences. The infrared spectral data revealed that the Schiff base coordinates to the metal ions through active sites which are –OH and –C=N groups. According to the electronic spectral data, an octahedral geometry was proposed for the chelates. The synthesized ligand and its metal chelates were screened for their antimicrobial activity against two Gram negative (Escherichia coli, Salmonella kentucky) and two Gram positive (Lactobacillus fermentum, Streptococcus faecalis) bacterial strains, unicellular fungi (Fusarium solani), and filamentous fungi (Aspergillus niger). The activity data showed that the metal chelates have antibacterial and antifungal activity more than the parent Schiff base ligand against one or more bacterial or fungi species. The results also indicated that the metal chelates are higher sensitive antimicrobial agents as compared to the Schiff base ligand.
Highlights
Schiff bases are most widely used as chelating ligands in coordination chemistry and have been investigated extensively for the past several decades leading to new synthetic routes of structure, biological, and industrial applications [1]
In the present study we have reviewed the synthesis and characterization of Schiff base and its chelates with Zr(IV), La(III), and Ce(IV) ions
The newly synthesized Schiff base chelates are very stable in air and generally soluble in DMF
Summary
Schiff bases are most widely used as chelating ligands in coordination chemistry and have been investigated extensively for the past several decades leading to new synthetic routes of structure, biological, and industrial applications [1]. They are useful in catalyst chemistry and in medicine (pharmacology) as antibiotic, antiallergic, and antitumor agents [2]. The complexes of the type MLXn, where M=VO(IV), Mn(II), Fe(III), Co(II), Ni(II), Zn(II) and Cd(II), X=H2 O/Cl− , and. The physicochemical data suggested a square pyramidal structure for VO(IV), pseudo octahedral structure for Cu(II), and an octahedral structure for Mn(II), Fe(III), Co(II), Ni(II), and.
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