Abstract

VARICELLA can be a life-threatening infection in immunocompromised patients. Because a large number of patients with primary or acquired immunodeficiencies are cared for at the University of Minnesota Health Sciences Center, we found it desirable to maintain a supply of zoster immune plasma for attempted prevention of varicelia in such patients. The results of ZIP prophylaxis in 31 of our immunocompromised patients were recently published? The present report expands our study to 50 patients, describes the kinetics of passively transferred varicella-zoster virus antibodies, and provides data suggesting that plasma should be transfused as soon as possible after exposure.

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