Abstract
Topiramate is the only approved oral preventive drug for chronic migraine (CM). However, we usually use other preventive drugs of prevention of frequent episodic migraine. Zonisamide is a neuromodulator that has showed efficacy in prevention of CM.
Highlights
Topiramate is the only approved oral preventive drug for chronic migraine (CM)
Zonisamide presents a good profile of efficacy (70.3% of responses) and an acceptable tolerance
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Summary
Zonisamide presents a good profile of efficacy (70.3% of responses) and an acceptable tolerance. It could be a useful therapeutic option in CM patients intolerants, refractory, or with contraindications for topiramate, and the other drugs preventive drugs of migraine
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