Abstract
Some patients who have secondary insomnia due to psychiatric disorder or physical illnesses tend to develop zolpidem dependence and even rare and severe complications such as withdrawal seizures. Psychiatric comorbidity seems to increase abuse and dependence tendency more than comorbidity of medical illnesses does. Herein, we present two cases of zolpidem dependence complicated with withdrawal seizures; the patients completed zolpidem detoxification and had different outcomes after discharge. Psychiatric comorbidity is probably a poor prognostic factor for abstinence from zolpidem.
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