Abstract
The Zollinger-Ellison syndrome (ZES) is characterized by gastrin-producing tumors, gastric acid hypersecretion, peptic ulcers, and diarrhea. ZES may be associated with nonpancreatic endocrine tumors as part of the multiple endocrine adenomatosis-type 1 syndrome. The diagnosis of ZES can be confirmed in patients with a suggestive clinical picture and excessive gastric acid secretion by the finding of a markedly elevated fasting serum gastrin level or characteristic gastrin response to provocative testing. Standard treatment of ZES has traditionally been surgical. With the introduction of H2-histamine receptor antagonists, however, many patients can now be managed successfully with cimetidine alone, or cimetidine plus vagotomy, when no resectable gastrinoma is present.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.