Zoledronik asit infüzyonu sonrası COVİD-19’u taklit eden akut faz reaksiyonu

Abstract

During the pandemic, symptoms of many diseases that can be confused with the symptoms of 
 COVID-19 have been detected and reported. In this case report, we reported a patient who showed 
 flu-like symptoms and sudden lymphopenia within two days of zoledronic acid infusion. A 40-year-old 
 female patient with a COVID-19 history was admitted to our hospital with abdominal pain. 
 Hypercalcemia due to parathyroid adenoma was detected. Zoledronic acid (5 mg) was given 
 intravenously for the treatment of hypercalcemia. Following the infusion; fever, C-Reactive Protein 
 (CRP) increase and lymphopenia were detected in the patient. There were no apparent causes to 
 explain these symptoms. The side effects we detected in the patient were confusingly similar to the 
 symptoms of COVID-19. Repeated PCR tests and CT results indicated that the patient did not have 
 COVID-19. A week later, the patient’s symptoms improved and the laboratory findings along with the 
 physical examination returned to normal. The patient's condition was considered to be due to 
 zoledronic acid infusion. We would like to draw attention to the acute phase reaction after zoledronic 
 acid infusion in the COVID-19 era in which the clinical situation could be confusing.