Abstract
The aim of this study was to evaluate the effect of zoledronic acid (ZA) on bone mineral density (BMD) in patients with prostate cancer receiving combined androgen blockade (CAB) as a first-line androgen deprivation therapy. Patients receiving CAB for prostate cancer without bone metastasis were candidates for this study. Forty-two patients were randomly assigned to receive either ZA or no treatment. BMD were measured at baseline and at 12 months. Bone-turnover markers, including cross-linked N-telopeptide of type I collagen (NTX), C-telopeptide of type I collagen (ICTP), and bone-specific alkaline phosphatase (BAP), were assessed during study periods. Patients on ZA maintained BMD after a year of treatment. Change in T-score from baseline differed significantly between the two groups (P=0.009). An inverse correlation was demonstrated between baseline and change in T-score in the ZA group. While ZA prevented an increase in ICTP and BAP, the increase in NTX was suppressed only in patients with low baseline T-score. ZA prevented a decrease in BMD in patients undergoing CAB, especially those with lower baseline BMD.
Highlights
Androgen deprivation therapy (ADT) is a standard option for patients with prostate cancer (PCa) who require systemic therapy
bone mineral density (BMD) At 1 year after treatment, patients on zoledronic acid (ZA) maintained their T-score (P = 0.74), while control patients experienced a significant decrease in T-score (−3.9%, P = 0.001)
The present study demonstrated that a single infusion of ZA at the time of initiation of combined androgen blockade (CAB) for ADT resulted in maintenance of BMD of the lumbar spine in men with PCa without bone metastasis
Summary
Androgen deprivation therapy (ADT) is a standard option for patients with prostate cancer (PCa) who require systemic therapy. While ADT is effective for PCa, this therapy can induce several side effects (Ahmadi & Daneshmand 2013). Long-term ADT can lead to decrease bone mineral density (BMD), a surrogate for fracture risk. Skeletal fractures are negative predictors of overall survival in patients with PCa (Oefelein et al 2002).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
