Abstract
Zoledronic acid 5 mg is an annually administered intravenous bisphosphonate that is approved for the treatment of osteoporosis. The Health Outcomes and Reduced Incidence with Zoledronic acid ONce yearly (HORIZON) Pivotal Fracture trial showed an increase in bone mineral density, decrease in bone turnover markers, and significant reduction in the risk of vertebral, hip and other fractures in women with postmenopausal osteoporosis treated over a period of 3 years. The HORIZON Recurrent Fracture Trial demonstrated that an annual infusion of zoledronic acid started within 90 days of surgical repair of a low-trauma hip fracture in women and men was associated with a significant decrease in the risk of new clinical fractures and an increase in survival. The tolerability and safety profile of treatment in both studies was generally favorable, with the most common adverse event being transient flu-like symptoms shortly after infusion.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
