ŞİZOFRENİ VE BİPOLAR BOZUKLUKLAR İLE ENFEKSİYON HASTALIKLARI ARASINDAKİ İLİŞKİNİN ARAŞTIRILMASI

Abstract

Aim: Considering the results of epidemiological studies, claimed that some congenital and postpartum infections in the intrauterine period, especially in 2nd Trimester, may play a role for the occurrence of Schizophrenia and Bipolar Disorder(BD). Aim of our study; serum samples of schizophreni-BD patients and healthy asymptomatic donors, Toxoplasma gondii (T.gondii), Chlamydia pneumoni (C.pneumoniae), Chlamydia trachomatis (C.trachomatis), Cytomegalovirus (CMV), Herpes simplex Virus(HSV1-HSV2), Treponema pallidum (T.pallidum) and Barnavirus which associated with psychic disorders evaluated using serological diagnostic methods and investigated the possible relationship of infections. Material and Methods: In this study, ELISA method was used for seroprevalence of congenital and postpartum infections. Also, Sandwich EIA method was used for Endogenous Bornavirus Like Nucleoprotein1(EBLN1) in peripheral blood samples. Results: Serum samples from 258 patients consisting of 96 female-162 male observed in psychiatry clinics and from healthy asymptomatic 150 donors including 100 male-50 female who came to the blood centers to donate blood. A significant difference wasn’t detected among seropositivity rates of CMV, HSV1-HSV2 and T.pallidum for patients and control groups. In statistical aspects, seroprevalence of T.gondii and C.pneumoniae in patients(93.02%-68.99%) were found significantly higher than the seropositivity rate of the control groups(63.33%-50%). Despite C.trachomatis showed a statistically significant difference between patients and control group of women compared to patients and control group of men, but significant difference weren’t detected in whole investigated population. BVLN1 was detected 4 men(2.46%) in the patient group. Conclusion: Based on study results, T.gondii and C.pneumoniae carry higher risk in patients with schizophrenia and BD compared to control ones.