Abstract
Introduction: Zinc oxide Nanoparticles (ZnO NPs) could lead to defects in chick craniofacial skeleton during embryogenesis, but the further mechanism is still not clear. In this study, we found ZnO NPs exposure cause craniofacial development defect, including shorten coracoids, curved coracoids and impaired parietal bone, which is derived from the cranial neural crest cells. we observed that ZnO NPs could inhibit the production and migration of cranial neural crest cells, which mainly caused by altering expression of epithelial-mesenchymal transitions-related adhesion molecules. Moreover, we observed that ZnO NPs significantly induced the extent apoptosis in cranial neural crest cells but not affect the cell proliferation. Then, the level of oxidant stress of cranial neural crest cells is elevated by ZnO NPs treatment.
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