Abstract
We report on scalable and position-controlled optical nanoprobe arrays using ZnO nanotube waveguides on graphene films for use in local optical excitation. For the waveguide fabrication, position-controlled and well-ordered ZnO nanotube arrays were grown on chemical vapor deposited graphene films with a submicron patterned mask layer and Au prepared between the interspace of nanotubes. Mammalian cells were cultured on the nanotube waveguide arrays and were locally excited by light illuminated through the nanotubes. Fluorescence and optogenetic signals could be excited through the optical nanoprobes. This method offers the ability to investigate cellular behavior with a high spatial resolution that surpasses the current limitation.
Highlights
High spatial resolution optical excitation is of great importance for improved understanding and fine control of living systems.[1,2,3] For example, it enables fundamental probing techniques in optogenetics[4,5] and uncaging of neurotransmitters[6,7] for accurate spatial mapping of neuronal activity
ZnO nanotube waveguide arrays on graphene films for local optical excitation on biological cells
We report on scalable and position-controlled optical nanoprobe arrays using ZnO nanotube waveguides on graphene films for use in local optical illumination
Summary
High spatial resolution optical excitation is of great importance for improved understanding and fine control of living systems.[1,2,3] For example, it enables fundamental probing techniques in optogenetics[4,5] and uncaging of neurotransmitters[6,7] for accurate spatial mapping of neuronal activity. ZnO nanotube waveguide arrays on graphene films for local optical excitation on biological cells We report on scalable and position-controlled optical nanoprobe arrays using ZnO nanotube waveguides on graphene films for use in local optical illumination.
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