ZnO Nanoporous Spheres with Broad-Spectrum Antimicrobial Activity by Physicochemical Interactions

Abstract

The extensive range of applications where synthetic nanomaterials are nowadays used is causing a huge commercial market. An incipient use of these nanomaterials arises from the need to generate alternative antimicrobial agents, anticipating the development of resistant microorganisms. Here, we show a nanostructured ZnO with antimicrobial properties and low cytotoxicity based on a nanoparticle’s arrangement by controlling the formation of sintering neck into nanoporous spheres. The antimicrobial effectiveness of ZnO spheres is tested in a broad spectrum of microorganisms such as fungi as well as Gram-negative and Gram-positive bacteria. The hierarchical structures show highly effective antimicrobial activity at low concentrations and in relatively short action times (24–72 h). We demonstrate that the enhanced antimicrobial properties against microorganisms are ascribed to a combining of both physical and chemical interactions between microorganism and ZnO. The approximation mechanism between microorganism ...