ZnO Nanoparticles: An Efficient Reagent, Simple and One-Pot Procedure for Synthesis of Highly Functionalized Dihydropyridine Derivatives

Marziyeh Khazaei,Bahareh Sadeghi,Mohammad Anary-Abbasinejad,Alireza Hassanabadi

doi:10.1155/2012/780470

Abstract

A new and efficient one-pot synthesis of dihydropyridones derivatives by four-component reaction between cyanoacetamide, aryl aldehydes, and ethyl acetoacetate with ammonium acetate using nano ZnO is described. The reaction was performed in ethanol under reflux conditions and afforded good yields of products.

Highlights

Substituted dihydropyridones derivatives are important intermediates in the pharmaceutical, dye and photo industries.[1] pyridones are of interest because of the occurrence of their saturated and partially saturated derivatives in biologically active compounds and natural products such as NAD nucleotides, pyridoxol, and pyridine alkaloids.[2]
We report a new and efficient one-pot synthesis of polysubstituted dihydropyridones derivatives by four-component reaction between cyanoacetamide, aryl aldehydes and ethyl acetoacetate with ammonium acetate using nano ZnO
The reaction was performed in ethanol under reflux conditions and afforded good yields of products. (Figure 1)

Summary

Introduction

Substituted dihydropyridones derivatives are important intermediates in the pharmaceutical, dye and photo industries.[1] pyridones are of interest because of the occurrence of their saturated and partially saturated derivatives in biologically active compounds and natural products such as NAD nucleotides, pyridoxol (vitamin B6), and pyridine alkaloids.[2]. A mixture of ZnO nanoparticles (10 mol%), aryl aldehydes 1 (1 mmol), and cyanoacetamide 2 (1 mmol) in ethanol (20 mL) was stirred at room temperature for 3h and was added to it a solution of , ethyl acetoacetate(1 mmol) 3 and NH4OAc(1 mmol) and was refluxed for 8h.

Results

Conclusion