Abstract
Microbial infectious are becoming a global threat, which is a reason for rise in mortality of human beings. One of the reasons for this mortality has been the drug resistance in microbes. The drug resistance poses a major challenge for effective control of microbial infections, and this threat has prompted us to search for alternative strategy to control the microbial infections. Recently, nanomaterials have emerged as an alternative to conventional platforms because they combine multiple mechanisms of action into one platform due to the distinctive properties of nanosized materials. In the present research we have attempted to synthesize ZnO/CdS nanocomposite for its application as an antimicrobial agent. We have characterized the synthesized nanocomposites by X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV-Vis), photoluminescence spectroscopy (PL), field emission scanning electron microscopy (FESEM) and high-resolution transmission electron microscopy (HRTEM). The nanocomposites have exhibited good antibacterial property against Gram positive and Gram-negative organisms by virtue of the generation of reactive oxygen species (ROS) inside the cells, as reflected by ruptured appearances in the FESEM micrographs. Apart from antimicrobial activity, it also inhibited biofilm formations in Pseudomonas aeruginosa, a causative organism in lung infection and burn associated infections.
Highlights
Emergence of the antibiotics resistance in pathogens has become a serious health problem which requires an immediate attention
Biofilms are defined as conglomerations of bacterial cells and it remains with extra polymeric substance (EPS)
EPS behaves as diffusion barrier and does not allow an entry of antibiotics inside the biofilm, thereby protecting cells residing inside the biofilm
Summary
Emergence of the antibiotics resistance in pathogens has become a serious health problem which requires an immediate attention. ZnO nanoparticles are having a very low efficiency for the separation of electron hole pairs due to fast recombination of charge carriers [10]; efforts have been made to suppression of the recombination of photogenerated electron-hole pairs in ZnO nanoparticles In this regard, ZnO nanoparticles have been doped or conjugated with other nanoparticles such as ZnO/CdTe for antimicrobial applications [11], ZnO/CdSe for photoelectrode for splitting water [12], ZnO/CdS for enhanced field emission behavior [13], ZnO/CdS for enhanced photocatalytic activity [14], ZnO/CdS for antibacterial activity [15], ZnO/CdS for enhanced photocatalytic H2 evolution [16], and ZnO/CdS nanocomposite for Solar cell [17]. We have attempted to enhance the photocatalytic efficiency ZnO nanoparticles by synthesizing a composite with CdS nanoparticles, and further evaluated its antimicrobial and antibiofilm
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