Abstract
Lyme neuroborreliosis (LNB) is the most common disseminated form of LB in Europe. It is a tick transmitted disease, caused by Borrelia burgdorferi sensu lato complex (Bb). There are numerous tests on the market for neuroborreliosis diagnostics, but none is reliable enough to confirm the diagnosis of LNB alone. Measuring antibody index (AI), although a gold standard test, is unable to distinguish current infection from a resolved one. Support can partially be found in CXCL-13 concentration follow up, which will decrease after successful therapy. Microbiology testing is just a support in establishing LNB diagnosis, and must be considered in conjunction with exposure history, clinical presentation, and other laboratory findings.
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