Abstract
AbstractA series of new phenanthroline‐based metal complexes, coordination polymers are synthesized using 1,10‐phenanthroline 2,9‐dicarboxylate (PDA) and different metal salts including tin (R‐1 to R‐3), manganese (R‐4), ruthenium (R‐5), and zinc (R‐6) respectively. The inhibitory activities of synthesized coordination compounds are evaluated towards COX‐2 (cyclooxygenase‐2) and 5‐LOX (5‐lipoxygenase) enzymes. Among all the metal‐organic coordination complexes, Zn‐PDA (R‐6) shows most prominent inhibitory activity than other systems with the IC50 value of 0.0524 μg/mL and 0.834 μg/mL for both COX‐2 and 5‐LOX enzymes, respectively. The synthesized systems were also evaluated for their activity against COX‐1 and standard COX‐2 inhibitors viz. Rofecoxib and Aspirin. The rationale for R‐6 being the most potent metal complex for dual COX‐2 and 5‐LOX inhibition is demonstrated using docking studies.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
