Abstract
Combination therapy is considered as a useful therapeutic strategy for tumor. Here, Zn-based MOF Zn-TPN was prepared for combination with chemotherapy and chemodynamic therapy. Co-precipitation method was used to obtain the antitumor system DOX&Mn@Zn-TPN, which incorporated DOX (9.37 wt%) and Mn2+ (5.75 wt%). The Fenton-like reaction of Mn2+ provided positive chemodynamic therapy, and drug release exhibited responses to pH, temperature and glutathione (GSH), enabling specific therapeutic effects in the tumor environment. According to the Korsmeyer-Peppas model, DOX release was a result of drug diffusion. In vitro cell experiments confirmed that the system exhibited significant lethality against 4T1 cells while maintaining biocompatibility with L929 cells.
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