Zirconia nanoparticles/carbon quantum dots modified carbon paste electrode as electrochemical sensor for determination of antiepileptic drug eslicarbazepine acetate in bulk and pharmaceutical dosage form

Abstract

A new, sensitive and selective electrochemical method has been developed for determination of the antiepileptic prodrug eslicarbazepine acetate (ESL) that is used for the treatment of partial-onset seizures in adults with epilepsy. It belongs to the class of sodium channel blockers called dibenzoazepine family. A novel modified zirconia nanoparticles carbon paste nanocomposite, carbon dots sensor prepared from banana peels by solvothermal method has been fabricated. The voltammetric method is based on the direct anodic oxidation of ESL at the electrode surface using differential pulse voltammetry. Under the optimum experimental conditions, ESL exhibited a linear relationship in the range of 3.04 × 10-8 to 9.66 × 10-5 M with a lower detection limit of 7.57 × 10-9 M and quantification limit of 2.29 × 10-8 M. The proposed method was validated according to ICH guidelines and was applied for estimating ESL in raw material showing high accuracy and precision with successful application on tablet dosage form.