Abstract
Three undescribed zinniol derivatives, arcopiniols A-C ( 1 - 3 ), together with three known compounds zinniol ( 4 ), 8-zinniol methyl ether ( 5 ), and maristachone B ( 6 ), were isolated from the endophytic fungus Arcopilus sp. YUD20001 associated with Gastrodia elata using various chromatographic separation techniques. Arcopiniol A ( 1 ) was a new compound, while the spectroscopic data of arcopiniols B-C ( 2 - 3 ) are reported here for the first time. Their structures were determined using spectroscopic methods and their absolute configurations were confirmed by performing TDDFT calculations. A putative biosynthetic pathway for all the compounds was proposed. The anti-inflammatory and cytotoxic activities of compounds 1 - 3 were investigated. • Three undescribed zinniol derivatives were isolated from Arcopilus sp. YUD20001. • The spectroscopic data of arcopiniols B-C were firstly reported. • The possible biosynthetic pathways for the five zinniol derivatives were proposed.
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