Abstract
The purpose of the present research was to understand the mechanisms underlying the development of gastric cancer, with the goal of developing effective targets for treating gastric cancer. The expression level of aldo-keto reductase family 1 member C1 in gastric cancer tissues or gastric cancer cell lines by reverse transcription-polymerase chain reaction and western blotting shows a clear elevation. However, reducing aldo-keto reductase family 1 member C1 gene expression by knockdown methods led to the prevention of malignant behaviors of gastric cancer, such as proliferation, migration, invasion, and epithelial-mesenchymal transition. Also, phosphoinositide 3-kinase/protein kinase B signaling was reduced by aldo-keto reductase family 1 member C1 knockdown. Additionally, zingiberensis newsaponin prevented the growth of gastric cancer by specifically targeting aldo-keto reductase family 1 member C1. It seems that aldo-keto reductase family 1 member C1 could be an important factor in predicting the outcome of gastric cancer, while zingiberensis newsaponin might be a new treatment option for gastric cancer.
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