Abstract
Here, we investigated the effects of Zingiber mioga extracts (FSH-ZM) on the moisturization and depigmentation of skin as well as wrinkle formation in UVB-irradiated HRM-2 hairless mice. The mice were divided into six groups as follows: normal control (NC), UVB-irradiated control (C), positive control 1 (PC1, L-ascorbic acid 200 mg/kg b.w.), positive control 2 (PC2, Arbutin 200 mg/kg b.w.), Z100 (FSH-ZM 100 mg/kg b.w.), and Z200 (FSH-ZM 200 mg/kg b.w.). The experiment spanned a period of 6 weeks. We found that FSH-ZM led to an increase in the expression of hyaluronan synthase 2, fibrillin-1, and elastin mRNAs, and showed improved skin hydration in HRM-2 hairless mice compared to that in the UVB-irradiated control group. Furthermore, FSH-ZM also inhibited the expression of inflammatory cytokines and wrinkle forming factors generated by UVB and reduced the formation of wrinkles in the test group relative to that in the control group by increasing collagen synthesis. Moreover, we found that FSH-ZM decreased the expression of melanogenesis factors, which improved depigmentation in UVB-irradiated hairless mice. These results suggest that Zingiber mioga can potentially be utilized to develop products aimed at improving skin moisturization and depigmentation and reducing wrinkle formation.
Highlights
In recent years, there has been increased consumer interest and desire for improved skin health
There were no significant differences in the aforementioned factors in all animals
Zingiber mioga (ZM) increased the production of hyaluronic acid by increasing the expression of genes such as HAS2, a skin moisturizing factor, and regulated the expression of genes involved in collagen synthesis in the dermal tissue
Summary
There has been increased consumer interest and desire for improved skin health. The action of reactive oxygen species (ROS), caused by continuous UV exposure, causes inflammatory reactions, and promotes the activity of a matrix metalloproteinase (MMP), known as collagenase, which inhibits collagen synthesis in the dermis and promotes wrinkle formation [6,7]. In response to these UV exposures, the body activates a defense mechanism by increasing tyrosinase activity which leads to melanin production. In this study, we evaluated the efficacy of ZM for skin moisturization and depigmentation, and wrinkle improvement in vivo, and assessed the feasibility of its utilization in the development of functional foods and cosmetics for skin health
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