Abstract
BackgroundThe study aims to analyse the action of zingerone in diabetes-related cardiac arrhythmias.MethodsDiabetes was induced by streptozocin while treatment groups received 20 mg/kg zingerone daily. Following extra seven weeks, electrocardiography, extraction of blood, urine and heart for biochemical analysis, histopathology and immunofluorescence were undertaken.ResultsThe suppression of QT and QTc prolongation in diabetic rats was indicative of prolonged cardiac repolarisation that was greatly reduced by zingerone treatment. In addition, the reduction in PR interval attested that zingerone improved AV delay in diabetic rats. The fibrogenic transforming growth factor β1 upregulation in diabetic hearts was suppressed by zingerone. The marked glycogen deposition and muscle degeneration seen in diabetic heart sections were also alleviated by zingerone. Furthermore, zingerone prevented the decrease in of the serum anti-inflammatory cytokine adiponectin in diabetics. The heightened levels of oxidative stress markers 8-isoprostane and uric acid in diabetic rats were suppressed. In the diabetic heart, the reduced catalase activity was improved and the excessive expression of angiotensin receptor 1 was inhibited by zingerone.ConclusionCardiac delayed repolarisation and AV conduction in rats with diabetes were halted by zingerone. It appears that inhibition of cardiac fibrosis and associated inflammation-oxidative stress signalling underpins the zingerone effect.
Highlights
A lifelong metabolic disease accompanied by oxidative stress and hyperglycaemia, diabetes mellitus gives rise to degenerative complications and tissue deterioration in different organs, including the heart [1]
The suppression of QT and QTc prolongation in diabetic rats was indicative of prolonged cardiac repolarisation that was greatly reduced by zingerone treatment
Several other disorders are accompanied by the cardiovascular risk of extension of heart-rate corrected QTc and QT interval duration that serves as markers of delayed cardiac repolarisation [7]
Summary
A lifelong metabolic disease accompanied by oxidative stress and hyperglycaemia, diabetes mellitus gives rise to degenerative complications and tissue deterioration in different organs, including the heart [1]. Diabetes mellitus often proves fatal as a result of cardiovascular complications [2]. A range of mechanisms causing tissue damage and cardiovascular system dysfunction are triggered by diabetes mellitus. Cardiac ischemia and dysfunction are considered to be caused by alterations in oxidative stress and hyperglycaemia [6]. Several other disorders are accompanied by the cardiovascular risk of extension of heart-rate corrected QTc and QT interval duration that serves as markers of delayed cardiac repolarisation [7]. A number of studies have indicated that diabetics are more likely to develop cardiac conduction irregularities, such as high-degree atrioventricular (AV) block [8]. The study aims to analyse the action of zingerone in diabetes-related cardiac arrhythmias
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