Abstract
Zinc uptake (transport and binding) by basolateral membrane vesicles was investigated using membranes derived from small intestines of rats fed zinc-adequate and zinc-deficient diets. Uptake was separated into saturable and nonsaturable (diffusion) components. Kinetic analysis of initial rates of the saturable component of uptake (at 1 min) indicates half maximal uptake (Km) by vesicles from zinc-adequate rats was observed at a medium Zn2+ concentration of 24 microM. The maximum Zn2+ uptake rate (Jmax) of the saturable component was 17 nmol/(mg protein.min). Dietary zinc intake did not affect these parameters. Zn2+ transport by the basolateral membrane may involve an ATP-driven mechanism.
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