Abstract
Zinc is an important component in the process of insulin synthesis, storage and secretion. Therefore beta cells need very efficient and special transporters to accumulate sufficient amounts of zinc in se-cretion vesicles. Recent studies suggest the zinc transporter eight (ZnT8) is a major autoantigen in type 1 di-abetes. It is a pancreatic beta-cell-specific zinc transporter,and plays an important role in the synthesis and secretion of insulin by affecting the concentration of zinc. ZnT8 autoantibodies are important for diagnosis and prediction in autoimmune diabetes, especially in subjects whose common autoantibodies are negative. The sin-gle nucleotide polymorphism of ZnT8 gene(SLC30A8)determines ZnT8 autoantibodies specificity. Key words: Zinc transporter eight; Autoantibody; Beta cell; Zinc; Type 1 diabetes mellitus
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