Abstract
The response of trace metals to host liver in tumor-bearing mice was studied based on the data that an increase of hepatic zinc metallothionein (Zn-MT) was correlated with tumor growth rates. Zn concentration and 65Zn uptake in liver, unlike pancreas, were elevated 9 days after tumor transplantation. When zinc sulfate was subcutaneously (s.c.) injected into the tumor-bearing mice, hepatic MT, unlike pancreatic MT, was induced dose-dependently and much more than that in control mice. In the case of s.c. injection with cadmium chloride or copper chloride, however, hepatic MT in both control and tumor-bearing mice was induced dose-dependently. Yet, the induction efficiency by these two metals was nearly the same between control and tumor-bearing mice. These results indicate the unique response to exogenous Zn in host liver of tumor-bearing mice. An efficient induction of hepatic MT by Zn may lead to a retention of Zn in liver of tumor-bearing mice. J. Trace Elem. Exp. Med. 10:243–248, 1997. © 1997 Wiley-Liss, Inc.
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