Abstract
Developing environmentally benign synthetic protocols such as reaction in water is a major challenge. However, many of the known methods carried out in an aqueous medium are not efficient at large scale and need purification involving volatile solvents. Heterogeneous catalysis by nanoparticles in aqueous medium is a possible solution. Therefore, we tested the use of heterogeneous zinc oxide nanoparticles to catalyse the synthesis of di-spiroindolizidine bisoxindoles at room temperature by three-component condensation in an aqueous medium via azomethine ylide-mediated 1,3-dipolar cycloaddition reaction. The products were obtained with regio- and diastereoselectivities, with yields ranging from 83 to 94%, in 60 min. Absolute structures of products were confirmed by single-crystal X-ray crystallography. A gram-scale reaction along with recyclability experiment of the heterogeneous catalyst was also performed. To establish the sustainability of the reaction presented, green chemistry matrixes were calculated and found to possess a high atom economy of 96.59% and small E-factor of 0.098. The presented method has advantages such as environmental friendly reaction conditions, use of inexpensive heterogeneous zinc oxide nanoparticle as catalyst, broad substrate scope, short reaction times, quantitative yields of complex di-spiroindolizidine bisoxindoles and absence of tedious purification procedure like column chromatography.
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