Abstract
We report herein general conditions for a zinc-mediated anionic cyclization of unstabilized ketone enolates. This anionic cyclization allows access to various carbocyclic architectures by utilizing abundant ketones and unactivated alkenes as precursors. The transformation is enabled by the use of Zn(TMP) 2 as base and Zn(OTf) 2 as an additive. The resulting alkylzinc species can be intercepted by electrophiles for tandem C–X and C–O bond formation. To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered.
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