Abstract
Bilateral adrenalectomy and long-term Summary corticosteroid therapy produced a sustained decrease in serum-zinc. In ten patients adrenalectomy resulted in serum-zinc deficiency within 1 week, and this decrease was maintained for at least 6 months. Six patients on long-term corticosteroids presented with delayed wound healing; they were given oral zinc supplements (660 mg. zinc sulphate per day) and wounds healed completely. These results are important clinically because corticosteroids are widely used drugs and because the maintenance of adequate zinc levels is essential for proper wound healing.
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