Abstract
The present paper deals with the study of the influence of rising citrate concentrations in blood plasma on the extent of the low-molecular-weight fraction of zinc in the biofluid. In addition to the results of an earlier work on the metal ion equilibria in the zinc-citrate-cysteinate system, the reliability of the computer simulations involved did require beforehand an investigation of the other potentially predominant mixed-ligand zinc citrate complexes in plasma. The potentiometric study of the ternary complexation between zinc citrate and -histidinate, -glutaminate, -threoninate are thus reported in turn. The computer simulations carried out on the basis of these results show the tendency for zinc to be excreted urinarily under the influence of high concentrations of citrate in blood plasma, for example due to hyperparathyroidism, or to exchanged transfusions to infants. On this occasion the influence of high levels of citrate in plasma on the mobilization of other naturally—occurring metal ions into their low- molecular-weight fraction is also given.
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