Zinc and Copper in antioxidant defense system in patients with chronic nonbacterial prostatitis

Abstract

Among men of working age chronic prostatitis is the most frequent urological sickness, and characteristic symptoms of it are frequent reason of the urological recourse. Therefore this excuses a search for new methods of examination and treatment of the patients with this pathology.The objective: purpose of our research was studying of level of Zinc and Copper in blood and ejaculate and specialty of antioxidic defense of the patients with chronic nonbacterial prostatitis.Materials and methods. Under supervision were 120 patients with chronic nonbacterial prostatitis, among them 60 patients with inflammatory chronic pelvic pain syndrome(category IIIA) and 60 patients with noninflammatory chronic pelvic pain syndrome (category IIIB). Microelements Zinc and Copper in whole blood an ejaculate were determined using atomic absorption spectrophotometry on C-115 PC. State of antioxidant defense was judged considering quantification of Catalase after A. Bach and S. Zubkova and Superoxide Dismutase.Results. A certain decrease of Zinc and increase of Copper were observed in both groups of patients with chronic nonbacterial prostatitis. More expressed decrease of Zinc and increase of Copper were observed in patients with inflammatory chronic pelvic pain syndrome. Also it was noted that with long duration of chronic nonbacterial prostatitis takes place the antioxidant enzymes level decrease. More expressed decrease was observed in patients with inflammatory chronic pelvic pain syndrome. As a result of correlation analysis it was found that there is certain dependence between level of Zinc, Copper in blood and antioxidant defense enzymes.Conclusion. With chronic nonbacterial prostatitis were observed decrease of Zinc and increase of Copper levels in blood as well as in ejaculate of the patients. More intense decrease of Zinc and increase of Copper were noted in patients with inflammatory chronic pelvic pain syndrome. Metabolic changes with shortage of Zinc and excess of Copper correlate with antioxidant system disbalance, that is with antioxidant defense level decrease.