Abstract
Zika virus infection during pregnancy may result in birth defects and pregnancy complications. We describe the Zika virus outbreak in pregnant women in the Dominican Republic during 2016-2017. We conducted multinomial logistic regression to identify factors associated with fetal losses and preterm birth. The Ministry of Health identified 1,282 pregnant women with suspected Zika virus infection, a substantial proportion during their first trimester. Fetal loss was reported for ≈10% of the reported pregnancies, and 3 cases of fetal microcephaly were reported. Women infected during the first trimester were more likely to have early fetal loss (adjusted odds ratio5.9, 95% CI 3.5-10.0). Experiencing fever during infection was associated with increased odds of premature birth (adjusted odds ratio1.65, 95% CI 1.03-2.65). There was widespread morbidity during the epidemic. Our findings strengthen the evidence for a broad range of adverse pregnancy outcomes resulting from Zika virus infection.
Highlights
In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Emerging Infectious Diseases
Describe characteristics of pregnant women and pregnancy outcomes of women infected with Zika virus during the Dominican Republic outbreak in 2016–2017, according to a retrospective report
Provide infant outcomes for pregnant women infected with Zika virus during the Dominican Republic outbreak in 2016–2017, according to a retrospective report
Summary
Upon completion of this activity, participants will be able to:. Describe characteristics of pregnant women and pregnancy outcomes of women infected with Zika virus during the Dominican Republic outbreak in 2016–2017, according to a retrospective report. Upon completion of this activity, participants will be able to:. Describe characteristics of pregnant women and pregnancy outcomes of women infected with Zika virus during the Dominican Republic outbreak in 2016–2017, according to a retrospective report. Provide infant outcomes for pregnant women infected with Zika virus during the Dominican Republic outbreak in 2016–2017, according to a retrospective report. Determine factors associated with birth outcomes and clinical implications of the findings for pregnant women infected with Zika virus during the Dominican Republic outbreak in 2016–2017, according to a retrospective report
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