Abstract
In the present work, a novel, portable and innovative eNose composed of a surface acoustic wave (SAW) sensor array based on zeolitic imidazolate frameworks, ZIF-8 and ZIF-67 nanocrystals (pure and combined with gold nanoparticles), as sensitive layers has been tested as a non-invasive system to detect different disease markers, such as acetone, ethanol and ammonia, related to the diagnosis and control of diabetes mellitus through exhaled breath. The sensors have been prepared by spin coating, achieving continuous sensitive layers at the surface of the SAW device. Low concentrations (5 ppm, 10 ppm and 25 ppm) of the marker analytes were measured, obtaining high sensitivities, good reproducibility, short time response and fast signal recovery.
Highlights
One of the great challenges of contemporary science is the efficient diagnosis of diseases using non-invasive techniques
The position and relative intensity of the diffraction maxima are in agreement with the literature for ZIF-8 and ZIF-67 frameworks [38,39,42]
A surface acoustic wave (SAW) eNose based on Love-wave sensors combined with ZIF-8, ZIF-67, ZIF-8/AuNP
Summary
One of the great challenges of contemporary science is the efficient diagnosis of diseases using non-invasive techniques. This strategy aims to provide a higher quality of life for humans and reduce the mortality rate. Exhaled breath, recognized mainly through the sense of smell, is a method that has long been used for disease diagnosis This method was abandoned due to the emergence of new accurate and effective techniques, despite being highly invasive. Over the last few decades, an important advance in gas analysis technologies has re-launched the idea of diagnosing diseases by analyzing exhaled breath. The conventional systems mentioned above are accurate but are bulky, expensive, and require highly-qualified
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