ZIF-8-incorporated nanoparticles of MgFe2O4 supported on graphene oxide: A ternary hybrid catalyst for the efficient synthesis of pyrazole-based pyrido[2,3-d]pyrimidine-diones

Abstract

An efficient and stable MgFe2O4 nanoparticles incorporated in zeolitic imidazolate framework-8 supported on graphene oxide (GO) was synthesized. Using the achieved heterogeneous catalyst including ZIF-8@GO@MgFe2O4, various pyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine-dione derivatives were synthesized through the one-pot five-component reaction of hydrazine hydrate, ethyl acetoacetate, 1,3-dimethyl barbituric acid, ammonium acetate, and aryl aldehydes in the absence of any solvent. Furthermore, it was found that such a new heterogeneous catalyst was simply recyclable and separable. This research introduces a green and suitable versatile to synthesize a class of organic compounds by simple work-up, facile recycling system, excellent yields, utilizing non-toxic materials, as well as short reaction times. X-ray diffraction spectroscopy (XRD), Furrier transforms infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy (EDX/Mapping), field emission scanning electron microscopy (FE-SEM), and Brunauer-Emmett-Teller (BET) analysis were used to characterization and structure elucidation of the catalyst.