Abstract
Limbic encephalitis (LE) is an inflammatory disease involving the brain’s limbic structures. Typical symptoms include memory deficits, behavioral changes, psychosis, and seizures. Frequently, it is associated with antibodies against the central nervous system (CNS). Serum and cerebrospinal fluid tests for anti-LGI1, GABABR, AMPAR, CASPR2, Hu, Ma2, and GAD must be performed, as positive results might underlie a specific tumor. Zic-4 antibodies are more likely linked to cerebellar dysfunction as paraneoplastic form related to small-cell lung cancer (SCLC).
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