Zero-Order Controlled Release of Water-Soluble Drugs Using a Marker Pen Platform.

Abstract

Zero-order drug release that releases drugs at a constant rate is beneficial to prolong the therapeutic effect and avoid the side effects of drugs. However, due to the weak interaction between the drug and the carrier, it is particularly challenging to achieve zero-order release of water-soluble drugs. Inspired by the marker pen, which stores the water-based ink in the sponge core and releases a constant amount of ink from the tip for writing, we explore the marker pen as a drug delivery platform to achieve zero-order release of water-soluble drugs. Through the capillary interaction between the material and water, the pen core can absorb the aqueous drug solution to encapsulate and store the water-soluble drug model sodium fluorescein (SF) and can release the encapsulated SF by moving the pen tip across the surface. The results show that the marker pen can release a constant amount of SF at the nanogram level per unit length of the line drawn with the pen, and the cumulative SF release amount has a linear relationship with the length of the line. In addition, the amount of released SF is linear with respect to the SF concentration in the aqueous solution. Moreover, the SF-filled marker pen has excellent long-term stability as evidenced by that the amount of SF released from the pen remains constant within two weeks after filling.