Abstract
Background This study was carried out to evaluate the biocompatibility of zeolite-silver-zinc (Ze-Ag-Zn) nanoparticles and their effect on the compressive strength of Mineral Trioxide Aggregate (MTA). Material and Methods Biocompatibility was evaluated by an MTT assay on the pulmonary adenocarcinoma cells with 0.05, 0.1, 0.25, 0.5, 1 and 5 mg/mL concentrations of Ze-Ag-Zn. For compressive strength test, four groups containing 15 stainless-steel cylinders with an internal diameter of 4 and a height of 6 mm were prepared and MTA (groups 1 and 2) or MTA + 2% Ze-Ag-Zn (groups 3 and 4) were placed in the cylinders. The compressive strength was evaluated using a universal testing machine 4 days after mixing in groups 1 and 3, and 21 days after mixing in groups 2 and 4. Results There was no significant difference between cytotoxicity of different concentrations. The highest (52.22±18.92 MPa) and lowest (19.57±5.76 MPa) compressive strength were observed in MTA group after 21 days and in MTA + 2% Ze-Ag-Zn group after four days, respectively. The effect of time and 2% Ze-Ag-Zn on the compressive strength were significant (P<0.05). Mixing MTA with Ze-Ag-Zn significantly reduced and passage of time from day four to 21 significantly increased the compressive strength. Conclusions Mixing MTA with 2% Ze-Ag-Zn had an adverse effect on the compressive strength of MTA, but this combination had no cytotoxic effects. Key words:Compressive strength, Cytotoxicity, Mineral Trioxide Aggregate, Nanoparticle, Zeolite-Silver-Zinc.
Highlights
Mineral Trioxide Aggregate (MTA) is a calcium silicate-based hydrophilic cement which is widely used in endodontics for perforation repair and root canal treatment due to several favorable characteristics like biocompatibility and the capacity to induce osteogenesis and cementogenesis [1,2,3]
Its long setting time and handling difficulties are among its disadvantages [4, 5].Various techniques have been proposed to improve the properties of MTA including the incorporation of different additives such as calcium chloride, Na2HPO4 and nanoparticles [6,7,8,9]
T-test showed no significant difference in relation to cytotoxicity in the study groups (P
Summary
Mineral Trioxide Aggregate (MTA) is a calcium silicate-based hydrophilic cement which is widely used in endodontics for perforation repair and root canal treatment due to several favorable characteristics like biocompatibility and the capacity to induce osteogenesis and cementogenesis [1,2,3]. Incorporation of silver-zeolite to MTA has resulted in an increase in its solubility and release of calcium and in a decrease in setting time. Compressive strength of hydraulic cement is as an indicator of its hydration reaction and is indirectly an indication of the setting process of the material. This physical property is affected by the type of MTA, the liquid with which it is mixed, the condensing pressure and techniques used to mix the powder and liquid [14,15]. This study was carried out to evaluate the biocompatibility of zeolite-silver-zinc (Ze-Ag-Zn) nanoparticles and their effect on the compressive strength of Mineral Trioxide Aggregate (MTA). Conclusions: Mixing MTA with 2% Ze-Ag-Zn had an adverse effect on the compressive strength of MTA, but this combination had no cytotoxic effects
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