Abstract
The affinity of zeolite nanoparticles (diameter of 8–12 nm) possessing high surface area and high pore volume towards human plasma proteins has been investigated. The protein composition (corona) of zeolite nanoparticles has been shown to be more dependent on the plasma protein concentrations and the type of zeolites than zeolite nanoparticles concentration. The number of proteins present in the corona of zeolite nanoparticles at 100% plasma (in vivo state) is less than with 10% plasma exposure. This could be due to a competition between the proteins to occupy the corona of the zeolite nanoparticles. Moreover, a high selective adsorption for apolipoprotein C-III (APOC-III) and fibrinogen on the zeolite nanoparticles at high plasma concentration (100%) was observed. While the zeolite nanoparticles exposed to low plasma concentration (10%) exhibited a high selective adsorption for immunoglobulin gamma (i.e. IGHG1, IGHG2 and IGHG4) proteins. The zeolite nanoparticles can potentially be used for selectively capture of APOC-III in order to reduce the activation of lipoprotein lipase inhibition during hypertriglyceridemia treatment. The zeolite nanoparticles can be adapted to hemophilic patients (hemophilia A (F-VIII deficient) and hemophilia B (F-IX deficient)) with a risk of bleeding, and thus might be potentially used in combination with the existing therapy.
Highlights
The affinity of zeolite nanoparticles possessing high surface area and high pore volume towards human plasma proteins has been investigated
This study provides an evidence for high specific adsorption of APOC-III and fibrinogen on EMTand FAU-zeolite nanoparticles
It was found that these NPs accelerate the time of blood clot formation, which can be adapted to hemophilic patients (hemophilia A (F-VIII deficient) and hemophilia B (F-IX deficient)) with a risk of bleeding, and might be potentially used in combination with the existing therapy
Summary
The affinity of zeolite nanoparticles (diameter of 8–12 nm) possessing high surface area and high pore volume towards human plasma proteins has been investigated. A high selective adsorption for apolipoprotein C-III (APOC-III) and fibrinogen on the zeolite nanoparticles at high plasma concentration (100%) was observed. While the zeolite nanoparticles exposed to low plasma concentration (10%) exhibited a high selective adsorption for immunoglobulin gamma (i.e. IGHG1, IGHG2 and IGHG4) proteins. Zeolites are low-density crystalline aluminosilicates possessing regular micropores (one-, two- and three-dimensional) with well-defined pore sizes and shapes. EMT- and FAU-type zeolites have very low framework density (FD = 12.7‒12.9 T/1000 Å), high porosity, diverse morphology and crystal sizes[11]. Unlike its cubic FAU polymorph that has only supercages (1.15 nm3), the EMT-zeolite has two cages: hypocage (0.61 nm3) and hypercage (1.24 nm3) due to different stacking of faujasite sheets As a result, it creates different catalytic and sorption properties for both materials[11]. The inhibition of LPL leads in the delay of degradation of triglyceride-rich particles (i.e. CM and VLDL), which is implicated in pathophysiological events such as cardiovascular diseases[19,20,21,22,23,24]
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