Year-end Sale % OFF 
Abstract
Zeolites are porous minerals with high absorbency and ion-exchange capacity. Their molecular structure is a dense network of AlO4 and SiO4 that generates cavities where water and other polar molecules or ions are inserted/exchanged. Even though there are several synthetic or natural occurring species of zeolites, the most widespread and studied is the naturally occurring zeolite clinoptilolite (ZC). ZC is an excellent detoxifying, antioxidant and anti-inflammatory agent. As a result, it is been used in many industrial applications ranging from environmental remediation to oral applications/supplementation in vivo in humans as food supplements or medical devices. Moreover, the modification as micronization of ZC (M-ZC) or tribomechanically activated zeolite clinoptilolite (TMAZ) or furthermore as double tribomechanically activated zeolite clinoptilolite (PMA-ZC) allows improving its benefits in preclinical and clinical models. Despite its extensive use, many underlying action mechanisms of ZC in its natural or modified forms are still unclear, especially in humans. The main aim of this review is to shed light on the geochemical aspects and therapeutic potentials of ZC with a vision of endorsing further preclinical and clinical research on zeolites, in specific on the ZC and its modified forms as a potential agent for promoting human brain health and overall well-being.
Highlights
Even though this study showed the extensive potential of tribomechanical activation of zeolite clinoptilolite (ZC) (TMAZ)/PMA-ZC in Alzheimer disease (AD), it is still an unexplored domain and several new and extensive studies are needed to establish its prominent role as a preventive treatment in AD and other neurological disorders
This exceptional ion-exchange capacity, as well as the surface area, are improved with micronization processes, in particular with the tribomechanical micronization processes used for TMAZ or PMA-ZC
Based on the data collected on animal models and on a few clinical trials, it can be speculated that the general state of wellbeing generated by ZC, and in particular by TMAZ and PMA-ZC, is due to its detoxifying, anti-inflammatory and antioxidant action in the intestine
Summary
The geological formation of natural zeolite indifference to synthetic zeolite involves different rock species, in particular, physio-chemical conditions of temperature and pressure. The zeolites ion exchange capacity and cationic exchange within its pores/channels mainly depend on its silicon and aluminum ratio [24] This ratio is important for the stability of ZC. The pores of the ZC, in addition to metal cations and water, can interact with other molecules and ionic groups of organic origin, such as ammonia and nitrates, which bind with different levels of affinity [26,27] Thanks to these exceptional ion interactions properties, ZC is considered as one of the key important inorganic cation exchangers and heavily applied in many industrial sectors such as in the treatment of waste-water, nuclear waste, cultivated fields, animal husbandry, or as oral supplementation in humans [5].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
