Zellzyklusspezifische Genexpression des Adeno-assoziierten Virus

Abstract

The adeno-associated virus type 2 (AAV2) has a biphasic life cycle. In absence of a helper virus, the AAV2 DNA can integrate into the host cell genome or persist as episome in the cell nucleus. Co-infection with a helper virus such as herpes simplex virus type 1 (HSV-1) leads to a productive AAV2 infection, particularly in cells in S/G2 phases. HSV-1 replication, which normally takes place in any phase of the cell cycle, becomes restricted to cells in G1 phase when AAV2 is present.